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Folding@home ("Folding at Home") (sometimes abbreviated as FAH or F@h) is a distributed computing (DC) project designed to perform computationally intensive simulations of protein folding and other molecular dynamics (MD), and to improve on the methods available to do so. It was launched on October 1, 2000, and is currently managed by the Pande Group, within Stanford University's chemistry department, under the supervision of Professor Vijay Pande.
Folding@home is the most powerful distributed computing cluster in the world, according to Guinness,[2] and one of the world's largest distributed computing projects.[3] The goal of the project is "to understand protein folding, misfolding, and related diseases."[4]
Accurate simulations of protein folding and misfolding enable the scientific community to better understand the development of many diseases, including sickle-cell disease (drepanocytosis), Alzheimer's disease, Parkinson's disease, Bovine spongiform encephalopathy, cancer, Huntington's disease, cystic fibrosis, osteogenesis imperfecta, alpha 1-antitrypsin deficiency, and other aggregation-related diseases.[5] More fundamentally, understanding the process of protein folding - how biological molecules assemble themselves into a functional state - is one of the outstanding problems of molecular biology. So far, the Folding@home project has successfully simulated folding in the 1.5 millisecond range[6] - which is a simulation thousands of times longer than it was previously thought possible to model.
The Pande Group's goal is to refine and improve the MD and Folding@home DC methods to the level where it will become an essential tool for MD research,[7] and to achieve that goal they collaborate with various scientific institutions.[8] As of June 24, 2010, seventy-three scientific research papers have been published using the project's work.[9] A University of Illinois at Urbana-Champaign report dated October 22, 2002 states that Folding@home distributed simulations of protein folding are